How is mesothelioma diagnosed?
The use of a combination of testing is needed for proper diagnosis of mesothelioma because it can be easily confused with other carcinomas of the lung as well as other diseases. Chest x-ray is often the first line in diagnostic studies and may show obliteration of the diaphragm and thickening of the pleura, however, it is not specific for mesothelioma. Computed tomography (CT) is more helpful in distinguishing tumor characteristics and the extent of infiltration in to the pleura and will show irregular pleural nodular thickening. Magnetic resonance imaging (MRI) with gadolinium-based contrast material may be useful in defining the extent of penetration into the diaphragm and chest cavity. Thoracoscopic biopsies are necessary to confirm the diagnosis and have 98% specificity for mesothelioma.