A thorough medical history may reveal exposure to asbestos in the past or the presence of suspicious symptoms. Physical examination is followed by x-rays of the affected area of the body (lungs, heart, or abdomen). Positive x-rays signal the need for a CT scan (computerized tomography) or MRI (magnetic resonance imaging) for a detailed analysis of body structures. When the location of the abnormal cells is known, biopsies are taken. Biopsy of lung tissues is done by thoracotomy since the tumor affects the outer lung surface. Abdominal biopsies are obtained via laparoscopy. In both cases, small incisions allow the surgeon to visualize the internal organs and to take tissue for pathological examination.
Surgery is often needed to determine the staging of the disease. This reveals whether the tumor is self-contained or has spread to adjacent structures or other more remote areas of the body. This information can then guide treatment.