Mesothelioma: Etiology and Pathophysiology
Mesothelial cells are found on surfaces of the pleural, peritoneal cavities as well as the testis.
Malignant transformation is uncommon but when it does occur it usually arises on the pleural surfaces (80%) or peritoneal surfaces (18%).
Tumors usually begin as discrete plaques or nodules on the pleural or peritoneal lining and as they progress they will form sheets that cover the entire surface of the involved area. It is not unusual to see malignant cells grow along drainage or thoracotomy tracts.
Asbestos exposure is the most common cause of the disease (80%). There is approximately a 20 to 40 year latent period from the time of asbestos exposure to the development of the disease.
Men are more commonly affected due to work exposure, however women may develop it due to second hand exposure from asbestos fibers carried home on clothes or other objects.
